- intestinal microbiota
Bacillus subtilis C-3102 < for human >
Bacillus subtilis C-3102 < for human >
Bacillus subtilis is a bacterial strain found in dry vegetation and soil that is closely related to the Bacillus subtilis natto bacterium used to make fermented soybeans (natto). Bacillus subtilis C-3102 reaches the gut in living form. It was selected from among many bacterial strains for its high potential to create health benefits by impacting the gut microbiome.
Research background
The Asahi Group’s research on microorganisms and fermented milk can be traced back to Calpis, a company that produced and released Japan’s first lactic acid bacteria beverage in 1919. Tests done on mice in the 1970s as part of a collaborative research project between Calpis (then still an independent company) and Riken found that longevity was promoted by a proprietary formulation of fermented milk made from lactic acid bacteria and yeast. This work has inspired the Asahi Group to study the gut microbiome and its component strains. The Group has pioneered gut microbiome research by refining cutting-edge microbiome analysis technology and seeking out materials providing health benefits via the gut microbiome.
Major research findings
- Increase in gut bifidobacteria
- Alleviation of constipation symptoms
- Alleviation of functional gastrointestinal disorder symptoms
- Alleviation of loose stool symptoms
Creating a society of health and abundance
The gut microbiome has recently been found to play a role in a wide range of medical conditions such as obesity, diabetes and depression. Many researchers in Japan and throughout the world are also attempting to treat and prevent various conditions by improving the gut microbiome. Drawing on the characteristics of Bacillus subtilis C-3102 should enable the Group to help treat and prevent a wide range of medical conditions.
Research information on Bacillus subtilis C-3102 < for livestock >
-
Paper
Effective bifidogenic growth factors cyclo-Val-Leu and cyclo-Val-Ile produced by Bacillus subtilis C-3102 in the human colonic microbiota model
-
Paper
Effect of Bacillus subtilis C-3102 on bone mineral density in healthy postmenopausal Japanese women: a randomized, placebo-controlled, double-blind clinical trial
-
Paper
Effect of Bacillus subtilis C-3102 on loose stools in healthy volunteers
-
Paper
Influence of Bacillus subtilis C-3102 on microbiota in a dynamic model of the gastrointestinal tract simulating human conditions