• blood pressure
  • vascular function
  • exercise fatigue

Lactotripeptide

Lactotripeptide

This is a peptide* found in Asahi Group's proprietary fermented milk formulation. Two types of peptides (VPP and IPP) that have been found to contribute to health are collectively called “lactotripeptides.”
*Peptides are chains of multiple amino acids. Fermented milk contains a number of different peptides produced by lactic acid bacteria during the fermentation process.

Research background

The Asahi Group’s research on lactic acid bacteria and fermented milk can be traced back to Calpis, a company that produced and released Japan’s first lactic acid bacteria beverage in 1919. Tests done on mice in the 1970s as part of a collaborative research project between Calpis (then still an independent company) and Riken found that longevity was promoted by a proprietary formulation of fermented milk made from lactic acid bacteria and yeast. This work inspired the Asahi Group to pioneer the study of lactic acid bacteria and fermented milk by scientifically describing the health-promoting components of fermented milk and improving the technology used to assess peptide functionality.

Major research findings

  • Blood pressure reduction
  • Better vascular endothelial function
  • Better vascular flexibility
  • Better blood flow
  • Reduced motor fatigue

Creating a society of health and abundance

Poor blood pressure and other circulatory disorders can have health impacts that range from minor (such as chills or fatigue) to major (such as heart disease or stroke). The Group should be able to help promote healthy life extension by scientifically describing the various functions of the lactotripeptides.

Research information on Lactotripeptide

  • Paper

    Effects of the bioactive peptides Ile-Pro-Pro and Val-Pro-Pro upon autonomic neurotransmission and blood pressure in spontaneously hypertensive rats

  • Paper

    Oral administration of the milk casein-derived tripeptide Val-Pro-Pro attenuates high-fat diet-induced adipose tissue inflammation in mice

  • Paper

    The milk-derived peptides Val-Pro-Pro and Ile-Pro-Pro attenuate arterial dysfunction in L-NAME-treated rats.

  • Paper

    Milk-derived peptides, Val-Pro-Pro and Ile-Pro-Pro, attenuate atherosclerosis development in apolipoprotein e-deficient mice: a preliminary study

  • Paper

    Accumulation of ACE Inhibitory Tripeptides, Val-Pro-Pro and Ile-Pro-Pro, in Vascular Endothelial Cells

  • Paper

    Repressive processing of antihypertensive peptides, Val-Pro-Pro and Ile-Pro-Pro, in Lactobacillus helveticus fermented milk by added peptides

  • Paper

    Effects of val-pro-pro and ile-pro-pro on nondipper patients: a preliminary study

  • Paper

    Effect of an Excess Intake of Casein Hydrolysate Containing Val-Pro-Pro and Ile-Pro-Pro in Subjects with Normal Blood Pressure, High-Normal Blood Pressure, or Mild Hypertension

  • Paper

    Milk casein-derived tripeptides, VPP and IPP induced NO production in cultured endothelial cells and endothelium-dependent relaxation of isolated aortic rings

  • Paper

    Casein hydrolysate containing Val-Pro-Pro and Ile-Pro-Pro improves central blood pressure and arterial stiffness in hypertensive subjects: A randomized, double-blind, placebo-controlled trial.

  • Paper

    Casein Hydrolysate containing the Antihypertensive Tripeptides Val-Pro-Pro and Ile-Pro-Pro Improves Vascular Endothelial Function Independent of ｂlood Pressure- Lowering Effects:Contribution of the Inhibitory Action of Angiotensin-Converting Enzyme

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